1st European Ovary Workshop

EMBO Workshop on Ovarian Biology:
1st European Ovary Workshop
All About Ovaries

15:00 WET

Registration TBA

17:00 WET

Welcome reception TBA

20:00 WET

07:00 WET

Registration TBA

08:30 WET

Opening ceremony TBA

09:00 WET

Keynote 1: Gonadal sex determination TBASusana Chuva Lopes

09:30 WET

Keynote 2: Meiosis and oogenesis TBAJennifer Gruhn

10:00 WET

Cohesin dynamics determine oocyte quality throughout the mammalian reproductive lifespan TBANeil Hunter

10:15 WET

Epigenetic regulation of female reproductive aging TBATahira Aslan Investigating the impact of pubertal onset on cohesion weakening in mouse oocytes TBALuz Maria Lopez Ruiz Morphological assessment of competence: creating a model for predicting blastocyst formation and euploidy status from oocyte characteristics TBAMichael Neal Preventing Supernumerary Oocyte Formation by Restricting Synaptonemal Complex Maintenance TBARui Gonçalo Martinho Reconstructing the ultrastructure of conserved ovarian intercellular bridges (ICBs) TBAJasmin Imran Alsous SMYD3 as a key epigenetic regulator of meiotic maturation and developmental competence in ovine oocytes TBAChiara Camerano Spelta Rapini

10:45 WET

11:15 WET

Keynote: Theca cells – the forgotten cells of the ovary TBAChristiani A. Amorim

11:45 WET

Mechanical control of mammalian folliculogenesis by theca cells and its implications in ageing TBAChii Chan

12:00 WET

Distinct differences in luteinization dynamics of cultured human granulosa cells from small antral follicles and preovulatory follicles TBALea Bejstrup Jensen Isolation and characterization of extracellular vesicles from maturation media conditioned by bovine oocytes TBA Isolation and propagation of human ovarian theca cells TBAMalene Louise Johannsen Luteinizing hormone (LH)- and choriogonadotropin (hCG)-dependent receptor trafficking is required to maintain ligand-specific signalling TBAClara Lazzaretti Molecular landscape of folliculogenesis and oogenesis across ovarian lifecycle stages TBADarina Obukhova Revealing ovarian homeostasis in Drosophila: A new model for ovarian physiology TBAVincent Mirouse Single-cell transcriptomics show a cell cycle response in ovarian mural granulosa cells of sows following a negative energy balance during lactation TBAYu Qi SLIT1 and SLIT2 act redundantly through AKT pathway in response to gonadotropins without exclusively signaling via ROBO1 in mouse follicular granulosa cells TBAFlorine Grudet The effect of luteinizing hormone (LH) in modulating Anti-Müllerian hormone (AMH) pathway in human granulosa cells TBASerena De Carlini

12:30 WET

Lunch + Networking event TBA

14:30 WET

Translational strategies targeting the ovarian microenvironment to improve reproductive longevity TBAFrancesca Duncan

15:00 WET

Single cell and spatial multiomics analysis of the ovary across the lifespan TBAJames Ashcroft

15:15 WET

A novel cellular player in ovarian biology: telocytes in the intraovarian stroma TBAMerjem Purelku AMH signaling in the ovary is mediated by stromal fibroblasts. Stroma-follicle interactions as a key to understanding follicle activation regulation TBAIlana Boustanai Assessing the ovarian microbiome: lack of a distinguishable microbial signature beyond contamination TBAAlberto Sola Leyva Development of a decellularized bovine ovarian tissue scaffold and its application in 3D culture of secondary follicles in a medium enriched with resveratrol-loaded nanoparticles TBAJosé Silva Extracellular vesicles in the ovarian follicle in health and disease: do they play only trivial roles in molecular cellular communication? TBAAgne Velthut-Meikas IGF-1, EGF and dbcAMP orchestration for gap-junction restoration between oocytes and cumulus cells TBATaisiia Yurchuk Mapping the human ovarian cortex: unravelling the proteomics landscape across life stages and chemotherapy exposures TBALoren Méar Preliminary results on the comparison of different techniques for isolation of extracellular vesicles from equine follicular fluid TBAFabiola Le Gaffric Molto Proteomic profiling reveals the molecular signature of chemotherapy-induced microenvironmental alterations in the human ovary TBAJohanne Grosbois

15:45 WET

16:15 WET

Keynote 1: Contribution of mechanical force to microenvironment for oocyte dormancy TBAKatsuhiko Hayashi

16:45 WET

Keynote 2: New methods for induced ovulation and gamete derivation in an endangered marsupial mammal TBAAndrew Pask

17:15 WET

Innovative Poly(epsilon-caprolactone)(PCL) electrospun patterned scaffolds: shaping the future of ovarian tissue engineering TBAChiara Di Berardino

17:30 WET

Developing an in vitro ovary model for the prolonged culture of mouse follicles TBAMira Jacobs Developing mouse ovarian organoids to explore reproductive health and disease TBALixian Liu Development of the in vitro culture of human preantral follicles for restoration of fertility in cancer patients TBAShunran Zhang Evaluation of adeno-associated virus (AAV)-mediated transduction of dissociated mouse ovarian cells TBAJanet Kwan Generation of novel human ovarian cell models in vitro TBALydia Wehrli Molecular and ultrastructural effects of in vitro culture on human ovarian cortical samples TBAXinchen Liu Ovarian rejuvenation: neonatal cell replacement revives age-related loss in ovarian self-organisation TBAJowi Olfers Silk-Ovarioids: Establishment and characterization of human ovarian primary cells 3D-model system TBAValentina Di Nisio The effect of the mitochondrial-targeted antioxidant Mitoquinol in human follicles and ovarian tissue in vitro TBACristina Subiran Adrados The role of in vitro culture medium in shaping human ovarian preantral follicle development and ECM secretion TBAArezoo Dadashzadeh

18:00 WET

Poster Session 1 + Drinks TBA

20:00 WET

Welcome Dinner Party – Quiz Night TBA

09:00 WET

Keynote 1: Age-related loss of heterochromatin in oocytes leads to meiotic molecular defects and maturation deficiency TBAMichael Klutstein

09:30 WET

Keynote 2: Forever young: lessons from the naked mole-rat ovary TBAMiguel Brieño-Enriquez

10:00 WET

Genetic and anthropometric determinants of age-related ovarian follicular reserve TBAIlmatar Rooda SkQ1 treatment prevents ovarian aging in mice TBANikoleta Nikou

10:30 WET

Age and Physical Activity Modulate the miRNA Cargo contained in Extracellular Vesicles derived from Follicular Fluid TBAMaria Soares Effects of estradiol treatment on body composition in a mouse model of menopause: impacts on fat distribution, lean mass, and bone volume TBAJie Yang Epigenetic aging in oocytes TBAYehudit Friedman Exploring the role of interferon signaling as a modifier of DNA-damage syndrome and gonadal ageing TBAMarva Bergman Genetic links between ovarian ageing, cancer risk and de novo mutation rates TBAStasa Stankovic Impact of minipubertal gonadotropin and estradiol surges on ovaries before puberty, during reproductive life and aging in mice TBANoalig Wyckens Investigating the effects of reduced SECISBP2 expression on ovarian function and aging in mice TBACarolina Buza-Tarn Large ovarian reserve and lack of aging-associated oocyte quality decline in non-mouse rodents TBALenka Gahurova Metabolic pathways to reproductive longevity: BCAA and DR insights from C. elegans TBAChen Lesnik

11:00 WET

11:30 WET

Keynote: New neuroendocrine pathways in the regulation of ovarian function TBARichard Anderson

12:00 WET

Revealing the secrets of ovulation TBAChristopher Thomas

12:15 WET

Vasorin Involvement in the Maintenance of the Ovarian Follicular Reserve TBA Characterization of cellular populations in the fetal ovary of the rabbit Oryctolagus cuniculus TBAMaëva Guy Development of human ovarian spheroids as an innovating 3D model to study female hormone-related disorders TBAMaria João Souza HIPK2 and IKK𝛃 dependent guardian of germ cells TAp63𝛂 phosphorylation is crucial for its stability and ovarian reserve maintenance TBAAnjali Kumari Impact of the P4 antagonist RU486 on VEGF and its receptor signaling during the in vivo shift from the preovulatory to the periovulatory phase of ovarian follicles TBAAnnunziata Mauro New potential role of Luteinizing Hormone in the maintenance and survival of ovarian reserve TBANicole Bertani Nucleoporin107 is a critical determinant of soma-germline communication, essential for ovarian development and function TBAOffer Gerlitz Nucleoporin107 regulates EGFR signaling in the ovarian soma, necessary for proper oocyte differentiation TBAMerav Gold The Dummerstorf high-fertility mouse line 1 – a worldwide unique model for increased female reproductive performance TBACarolin Ludwig

12:50 WET

Sponsor Talk: Cryo Bio System TBA

13:00 WET

Sightseeing: Boat trip + lunch TBA

20:00 WET

09:00 WET

Keynote: In vitro maturation of immature oocytes in women with PCOS TBAMichel De Vos

09:30 WET

The effect of chronic inflammation on female fertility, oocyte epigenetics, and oocyte quality TBAStephen Ameho

09:45 WET

An investigation of the genetic association between low ovarian reserve and female malignancy TBANatalie Getreu Challenges in managing FOXL2-related follicular arrest: when modern IVF and tissue preservation fall short TBAPedro Melo Follicular fluid concentrations of the vitamin D metabolite 24,25(OH)2D3 are positively associated with live birth rate after ART TBAIreen Kooij Mesenchymal stromal cell secretome and its evaluation in the treatment of Polycystic Ovary Syndrome TBAAlessia Ventura Mild chronic variable stress promotes female fertility via the ovarian CRF receptor TBAEran Gershon The power of near-infrared photobiomodulation therapy on rescue in vitro maturation of human oocytes TBAPaola Scaruffi TUBB8 mutations and oocyte immaturity: screening, IVF outcomes and therapeutical perspectives : a systematic review TBAMargot Lherbet

10:15 WET

10:45 WET

Keynote: Assessing toxicity in human ovaries - from exposures and epidemiology to in vitro models TBAPauliina Damdimopoulou

11:15 WET

Impact of cannabis on human oocytes and IVF outcomes: an extensive in vitro and clinical investigation TBACyntia Duval

11:30 WET

Cannabis alters human granulosa cell steroidogenesis and luteinization TBABrandon Wyse Effects of phthalates on the 3D spheroid cell culture as a model for the human ovarian extracellular matrix TBASaba Nikanfar Hypo- and Hyper-methylation in oocytes correlates with altered folliculogenesis following exposure to an estrogenic endocrine disruptor TBADeidre Mattiske Perinatal exposure to Bisphenol A impairs the ovarian follicle dynamics and its extracellular milieu TBAEllen Leonel Repercussions of estrogen replacement therapy against BPA-induced ovarian disruption in a rodent model TBAThalles Ruiz Scoping review of the association between ultra-processed food and female fertility: current evidence and research gaps TBAHeidi Long Secondary effects of thyroid hormone disrupting chemicals on the ovary transcriptome – identification of effect biomarkers TBAHanna Johansson Single-cell insights on the effects of the phthalate metabolite MEHP on the human ovary in vitro TBAEleftheria Panagiotou

12:00 WET

Generation of functional oocytes by sex chromosome correction in vitro TBAKenta Murakami Impact of maternal aging on oocyte DNA repair and female fertility TBANinadini Sharma Investigating ribosome dynamics in the aging mammalian oocyte TBAAnna Galligos The Multispecies Ovary Tissue Histology Electronic Repository (MOTHER): A resource for science, education and data sharing TBAKaren Watanabe

13:00 WET

14:30 WET

Keynote: New insights to ovarian tissue cryopreservation and transplantation TBAStine Gry Kristensen

15:00 WET

Ovarian tissue after thawing: metabolic recovery and hormonal effects in follicle preservation, apoptosis and angiogenesis TBARebekka Einenkel

15:30 WET

A novel platform for cutting-edge cancer research is a tumor-infiltration mimicking model of contaminated ovarian tissue TBASaeid Moghassemi Antioxidant potential of eugenol derivatives: a preliminary study for ovarian tissue cryopreservation TBAFelipe Silva Biomechanical assessment of human ovarian cortex after vitrification and slow freezing procedures TBAMarta Mendez Can UCMSCs improve the integrity and mitochondrial function of cryopreserved ovarian grafts? TBAInês Moniz Circulating cell-free DNA and miR 502-3p are new predictive biomarkers of fertility preservation outcome in patients with breast cancer TBASophie Brouillet Effect of freezing and culturing ovarian tissue on follicle development in prepubertal girls TBANilay Kuscu Effect of prolonged cooling on metabolism of ovarian tissues in transport: TOM20 as a biomarker of mitochondrial function TBAEmmerson Teas Evaluating follicular outcomes during ex vivo photodynamic therapy in ovarian tissue TBAYuting Wan Molecular regulation of in vitro matured human oocytes in connection with ovarian tissue cryopreservation TBAJesus Cadenas Optimization of freezing and thawing protocols for human ovarian tissue cryopreservation through thermophysical characterisation of freezing medium by Differential Scanning Calorimetry TBAGaëlle Marteil Optimization of ovarian tissue transplantation through biomaterials: a scoping review TBAAna Sofia Pais What is the impact of transport time on the quality of ovarian tissue prior to cryopreservation? A comparison of post-transplantation success rates with findings at the proteomic, gene expression and histological... TBAIwona Scheliga

16:15 WET

16:45 WET

Activation or Apoptosis: Combined suppression of intrinsic and extrinsic follicle activation pathways completely prevents cyclophosphamide-induced follicle loss, while DNA damage doesn't end in oocyte apoptosis... TBAOren Kashi

17:00 WET

Anti-Mullerian hormone protects human ovarian follicles and stromal cells from immediate and sustained cyclophosphamide-induced damage in vitro TBARoseanne Rosario Clinical and ethical perspectives of performing ovarian stimulation and oocyte cryopreservation in adolescents: 6 years experience from a tertiary centre TBAEphia Yasmin Evaluating the gonadotoxicity of carboplatin and paclitaxel exposure on the ovary from young breast cancer patients carrying a BRCA mutation TBAJoana Dias Nunes Fertility preservation for girls undergoing cancer treatments or other gonadal toxic therapies TBAPeter Kilbride From Storage to Survivorship: Exploring the Experiences and Needs of Childhood Cancer Survivors with Stored Ovarian Tissue TBARebecca Mottram Molecular and functional impact of X-ray on primary ovarian cells TBASpyridon Panagiotis Deligiannis The protective effects of Aloe vera extract against doxorubicin-induced degeneration in mice ovarian follicles and stromal cells TBAMiguel Fernandes Use of factors released from human adipose stem cells for ovarian tissue regeneration TBAGiorgia D'Addato Use of long-acting GnRH trigger for fertility preservation patients TBAClaudia Massarotti

17:30 WET

Keynote: Harmony in diversity – ovarian biology in wild animal species TBAPierre Comizzoli

18:00 WET

Poster Session 2 + Drinks TBA

20:00 WET

Gala Dinner TBA

09:00 WET

Keynote: Importance of patient and public involvement TBAYvonne O’Meara

09:30 WET

Panel discussion TBAHajra Khattak • Richard Anderson • Daisy Ella

10:00 WET

10:30 WET

Keynote: Coordinating ovarian research TBAHajra Khattak

10:50 WET

Keynote: Ethics in ovarian research TBASeppe Segers

11:20 WET

Keynote: Nature’s SAFE & The Rhino Fertility Project TBASuzannah Williams

11:40 WET

Closing ceremony TBA

12:00 WET

Lunch and Goodbye TBA